Scientists organize millions of proteins by shape, as predicted by AI, revealing 700,000 new families and some shapes unique ...

Drug development and production rely on stringent quality controls, reproducibility, and verification. Biopharmaceuticals, including protein-based therapies, require extensive characterization, ...

The human leukocyte antigens (HLA-I) are multi-subunit complexes that localize to the cell surface and present bound peptides to nearby immune cells. The study of these HLA peptide-presenting ...

Researchers at the University of Toronto have developed a deep-learning model, called PepFlow, that can predict all possible shapes of peptides – chains of amino acids that are shorter than proteins, ...

Researchers outline how they used a chemical probe to light up interlocking peptides. Their technique will help scientists differentiate synthetic peptides from toxic types found in Alzheimer's ...

Controlling the topology and structure of entangled molecular strands is a key challenge in molecular engineering, particularly when attempting to create large nanostructures that mimic biological ...

Most natural proteins are fragile, degrading at high temperatures, in harsh solvents or under mechanical stress. Previous ...

A four–amino acid peptide called CAQK has shown powerful brain-protective effects in animal models of traumatic brain injury. Delivered through a standard IV, it zeroes in on injured brain tissue, ...

Tumors frequently express unmutated self-tumor–associated antigens (self-TAAs). However, trial results using self-TAAs as vaccine targets against cancer are mixed, often attributed to deletion of T ...

Peptides are short chains of amino acids, which differ from proteins due to their short length and can include two or more amino acids. 3 Protein-protein interactions underlie many critical cellular ...